Jay-
I am running 219 for clearance between the rear sprocket and rear cross rail on my new frame. (Smaller chain and smaller diameter sprockets) On my old frame I had more clearance and had no issues running #35 chain. I am using split sprockets inboard.
I just didn’t know if it was acceptable to add/remove links as needed or if it would be better to just make seperate lengths of chain for each ratio combo.