To answer your question, IAME motors were designed from the ground up to be kart racing motors, so they don’t have nearly the room for improvement through blueprinting that the KT-100 has. You can run competitively right out of the box, and a lot of people do. Certainly at a local-and-occassional-regional level.
Not sure why you can’t run the PRD where ever you plan to run a Leopard. The PRD is basically a Leopard clone, and I’ve watched decent drivers in PRD’s have good local success against Leopards.
The Leopard is being phased out so if you are buying new, the X-30 is the way to go. Neither should be more expensive to run than a PRD. The X-30 should have a longer rebuild cycle than the Leopard (30 hours versus 20, depending on how hard you drive).
However, there are a couple of new Leopards on sale here: http://www.italianmotorsusa.com/products/leopard-my09